Publications

  • Khezerlou, E., Saenz, J., Prakash, S.S., Pan, P.Y. (2024) Protocol for live neuron imaging analysis of basal surface fraction and dynamic availability of the dopamine transporter using DAT-pHluorin. STAR Protoc. PDF link
  • Saenz, J., Khezerlou, E., Aggarwal. M., Shaikh, A., Ganti, N., Herborg, F., Pan, P.Y. (2024) Parkinson’s disease gene, Synaptojanin1, dysregulates the basal maintenance of the dopamine transporter. npj Parkinson’s Disease PDF link
  • Mejaes, J.I., Saenz, J., O’brien, C., Pizzano, C.M., Pan, P.Y., Barker, D.J. (2024) Haploinsufficiency of the Parkinson’s disease gene Synaptojanin1 is associated with abnormal responses to psychomotor stimulants and mesolimbic dopamine signaling. Frontiers in Behavioral Neuroscience 18:1359225. PMID: 39050701 doi: 10.3389/fnbeh.2024.1359225 PDF link
  • Zhu X, Prakash SS, McAuliffe G, Pan PY. Synaptojanin1 Modifies Endolysosomal Parameters in Cultured Ventral Midbrain Neurons. eNeuro 2023, 10(5):ENEURO.0426-22.2023. PDF link
  • Saenz J, Yao O, Khezerlou E, Aggarwal M, Zhou X, Barker DJ, DiCicco-Bloom E, Pan PY. Cocaine-regulated trafficking of dopamine transporters in cultured neurons revealed by a pH sensitive reporter. iScience 2022, 26(1):105782. doi: 10.1016/j.isci.2022.105782. PDF link
  • Choudhry, H., Aggarwal, M., Pan, P.Y. Mini-review: Synaptojanin 1 and its implications in membrane trafficking. Neurosci Lett. 2021, 765:136288. doi: 10.1016/j.neulet.2021.136288. PDF link
  • Pan, P.Y.*, Zhu, J., Rizvi, A., Zhu, X., Tanaka, H., Dreyfus, C.F. Synaptojanin1 deficiency upregulates basal autophagosome formation in astrocytes. Journal of Biological Chemistry 2021, 297(1):100873. doi: 10.1016/j.jbc.2021.100873. * correspondence PDF link
  • Pan, P.Y.*, Sheehan, P., Wang, Q., Zhang, Y., Zhu, X., Wang, J., Li, X., Choi, I., Li, X., Saenz, J., Zhu, J., El Gaamouch, F., Zhu, L., Cai, D., and Yue, Z*. SYNJ1 Haploinsufficiency Causes Dopamine Neuron Vulnerability and α-synuclein Accumulation in Mice. Human Molecular Genetics 2020, https://doi.org/10.1093/hmg/ddaa080  *co-correspondence PDF link
  • Wang, Q., Zhang, Y., Wang, M., Song, W.M., Shen, Q., McKenzie, A., Choi, I., Zhou, X., Pan, P.Y., Yue, Z., Zhang, B. The landscape of multiscale transcriptomic networks and key regulators in Parkinson’s disease. Nature Communications 2019, 10(1):5234. PDF link
  • Pan, P.Y., Zhu, Y., Shen, Y., and Yue, Z. Crosstalk between presynaptic trafficking and autophagy in Parkinson’s disease. Neurobiology of Disease 2018, pii: S0969-9961(18)30136-0, PDF link
  • Pan, P.Y., Li, X., Wang, J., Powell, J., Wang, Q., Zhang, Y., Chen, Z., Wicinski, B., Hof, P., Ryan, T.A. and Yue, Z. Parkinson’s disease associated LRRK2 hyperactive kinase mutant disrupts synaptic vesicle trafficking in ventral midbrain neurons. Journal of Neuroscience 2017, 37(47): 11366-11376. PDF link
  • Pan, P.Y., Marrs, J., and Ryan, T.A. Vesicular glutamate transporter 1 orchestrates recruitment of other synaptic cargo proteins during synaptic vesicle recycling. Journal of Biological Chemistry 2015, 290(37): 22593-601. PDF link
  • Pan, P.Y., and Yue Z. Genetic causes of Parkinson’s disease and their links to autophagy regulation. Parkinsonism and related disorders 2014, 20 Suppl 1: S154-7. PDF link
  • Sun, T., Qiao, H., Pan, P.Y., Chen, Y., and Sheng, Z.H. Motile axonal mitochondria contribute to the variability of presynaptic strength. Cell Reports 2013, 4(3): 413-9. PDF link
  • Pan, P.Y. and Ryan, T.A. Calbindin controls release probability in ventral tegmental area dopamine neurons. Nature Neuroscience 2012, 15(6): 813-5. PDF link
  • Pan, P.Y., Tian, J.H. and Sheng, Z.H. Snapin facilitates the synchronization of synaptic vesicle fusion. Neuron 2009, 61(3): 412-24. Work recognized in reviews from distinguished scientists in Faculty1000, including a Nobel Laureate Erwin Neher. PDF link
  • Kang, J.S., Tian, J.H.*, Pan, P.Y.*, Zald, P., Li, C., Deng, C., and Sheng, Z.H. Docking of Axonal Mitochondria by Synataphilin Controls Their Mobility and Contributes to Short-term Facilitation. Cell 2008, 132(1):137-48. (*equal contribution)  PDF link
  • Cai, Q., Pan, P.Y. and Sheng, Z.H. Syntabulin-kinesin-1 family 5B-mediated axonal transport contributes to activity-dependent presynaptic assembly. Journal of Neuroscience 2007, 27: 7284-7296. PDF link
  • Pan, P.Y., Cai, Q., Lin, L., Lu, P.H., Duan, S., Sheng, Z.H. SNAP-29-Mediated Modulation of Synaptic Transmission in Cultured Hippocampal Neurons.  Journal of Biological Chemistry 2005, 280 (27): 25769-25779. PDF link

Upcoming Publications

June

2026

Synaptojanin1 regulates synaptic dopamine release and axonal integrity via retromer-dependent endosomal sorting

Nirmal Kumar, Elnaz Khezerlou, Jacqueline Saenz, Justin Cai, Hana Caiola, Shlok Nayak, Eden Lee, Ulrik Gether, Huaye Zhang, Ping-Yue Pan

Preprint