Publications

Khezerlou, E., Saenz, J., Prakash, S.S., Pan, P.Y. (2024) Protocol for live neuron imaging analysis of basal surface fraction and dynamic availability of the dopamine transporter using DAT-pHluorin. STAR Protoc. PDF link

Saenz, J., Khezerlou, E., Aggarwal. M., Shaikh, A., Ganti, N., Herborg, F., Pan, P.Y. (2024) Parkinson’s disease gene, Synaptojanin1, dysregulates the basal maintenance of the dopamine transporter. npj Parkinson’s Disease PDF link

Mejaes, J.I., Saenz, J., O’brien, C., Pizzano, C.M., Pan, P.Y., Barker, D.J. (2024) Haploinsufficiency of the Parkinson’s disease gene Synaptojanin1 is associated with abnormal responses to psychomotor stimulants and mesolimbic dopamine signaling. Frontiers in Behavioral Neuroscience 18:1359225. PMID: 39050701 doi: 10.3389/fnbeh.2024.1359225 PDF link

Zhu X, Prakash SS, McAuliffe G, Pan PY. Synaptojanin1 Modifies Endolysosomal Parameters in Cultured Ventral Midbrain Neurons. eNeuro 2023, 10(5):ENEURO.0426-22.2023. PDF link

Saenz J, Yao O, Khezerlou E, Aggarwal M, Zhou X, Barker DJ, DiCicco-Bloom E, Pan PY. Cocaine-regulated trafficking of dopamine transporters in cultured neurons revealed by a pH sensitive reporter. iScience 2022, 26(1):105782. doi: 10.1016/j.isci.2022.105782. PDF link

Choudhry, H., Aggarwal, M., Pan, P.Y. Mini-review: Synaptojanin 1 and its implications in membrane trafficking. Neurosci Lett. 2021, 765:136288. doi: 10.1016/j.neulet.2021.136288. PDF link

Pan, P.Y.*, Zhu, J., Rizvi, A., Zhu, X., Tanaka, H., Dreyfus, C.F. Synaptojanin1 deficiency upregulates basal autophagosome formation in astrocytes. Journal of Biological Chemistry 2021, 297(1):100873. doi: 10.1016/j.jbc.2021.100873. * correspondence PDF link

Pan, P.Y.*, Sheehan, P., Wang, Q., Zhang, Y., Zhu, X., Wang, J., Li, X., Choi, I., Li, X., Saenz, J., Zhu, J., El Gaamouch, F., Zhu, L., Cai, D., and Yue, Z*. SYNJ1 Haploinsufficiency Causes Dopamine Neuron Vulnerability and α-synuclein Accumulation in Mice. Human Molecular Genetics 2020, https://doi.org/10.1093/hmg/ddaa080  *co-correspondence PDF link

Wang, Q., Zhang, Y., Wang, M., Song, W.M., Shen, Q., McKenzie, A., Choi, I., Zhou, X., Pan, P.Y., Yue, Z., Zhang, B. The landscape of multiscale transcriptomic networks and key regulators in Parkinson’s disease. Nature Communications 2019, 10(1):5234. PDF link

Pan, P.Y., Zhu, Y., Shen, Y., and Yue, Z. Crosstalk between presynaptic trafficking and autophagy in Parkinson’s disease. Neurobiology of Disease 2018, pii: S0969-9961(18)30136-0, PDF link

Pan, P.Y., Li, X., Wang, J., Powell, J., Wang, Q., Zhang, Y., Chen, Z., Wicinski, B., Hof, P., Ryan, T.A. and Yue, Z. Parkinson’s disease associated LRRK2 hyperactive kinase mutant disrupts synaptic vesicle trafficking in ventral midbrain neurons. Journal of Neuroscience 2017, 37(47): 11366-11376. PDF link

Pan, P.Y., Marrs, J., and Ryan, T.A. Vesicular glutamate transporter 1 orchestrates recruitment of other synaptic cargo proteins during synaptic vesicle recycling. Journal of Biological Chemistry 2015, 290(37): 22593-601. PDF link

Pan, P.Y., and Yue Z. Genetic causes of Parkinson’s disease and their links to autophagy regulation. Parkinsonism and related disorders 2014, 20 Suppl 1: S154-7. PDF link

Sun, T., Qiao, H., Pan, P.Y., Chen, Y., and Sheng, Z.H. Motile axonal mitochondria contribute to the variability of presynaptic strength. Cell Reports 2013, 4(3): 413-9. PDF link

Pan, P.Y. and Ryan, T.A. Calbindin controls release probability in ventral tegmental area dopamine neurons. Nature Neuroscience 2012, 15(6): 813-5. PDF link

Pan, P.Y., Tian, J.H. and Sheng, Z.H. Snapin facilitates the synchronization of synaptic vesicle fusion. Neuron 2009, 61(3): 412-24. Work recognized in reviews from distinguished scientists in Faculty1000, including a Nobel Laureate Erwin Neher. PDF link

Kang, J.S., Pan, P.Y.*, Tian, J.H.*, Zald, P., Li, C., Deng, C., and Sheng, Z.H. Docking of Axonal Mitochondria by Synataphilin Controls Their Mobility and Contributes to Short-term Facilitation. Cell 2008, 132(1):137-48. (*equal contribution)  PDF link

Cai, Q., Pan, P.Y. and Sheng, Z.H. Syntabulin-kinesin-1 family 5B-mediated axonal transport contributes to activity-dependent presynaptic assembly. Journal of Neuroscience 2007, 27: 7284-7296. PDF link

Pan, P.Y., Cai, Q., Lin, L., Lu, P.H., Duan, S., Sheng, Z.H. SNAP-29-Mediated Modulation of Synaptic Transmission in Cultured Hippocampal Neurons.  Journal of Biological Chemistry 2005, 280 (27): 25769-25779. PDF link

Pan, P.Y., Lu, P.H., and Sheng, Z.H. The Structural and Molecular Mechanism of Neuronal Presynaptic Plasticity. Progress in Biochemistry and Biophysics. 2004, 31(7)